Analyses were conducted with hybrid imputation of missing body weight at 72 weeks and statistical inference over hybrid imputation of missing data guided by Rubin 47
If a diagnosis cant be made with certainty, the safest approach can be to treat these as genuine seizures (e.g., with benzodiazepine, airway protection)
Based on the monthly dosing efficacy and tolerability demonstrated in this trial, we remain confident in our plan to include a higher 9.6 mg monthly maintenance dose of PF3944 in [Phase III]. Pfizer noted that detailed results from the study are scheduled to be presented at the How does tolerability compare with established GLP-1 therapies
doi:10.1038/s41598-023-45870-1
Patients with CKD may require potassium restriction rather than supplementation, highlighting the importance of personalised nutritional guidance from a healthcare professional
Given its profound effects on inhibiting lipofuscin accumulation, TZP could be a valuable experimental tool in understanding the complex regulation mechanisms of lipofuscin
