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Retatrutide's glucose-dependent mechanism means hypoglycaemia risk is lower than with sulphonylureas or insulin when used alone, but the risk increases significantly when it is combined with other glucose-lowering medicines such as insulin or sulphonylureas, and dose reductions of those medicines may be required

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In addition to weight reduction, treatment with Semaglutide has decreased HbA1C levels in most individuals in clinical trials

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