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GIP(3-30)NH 2 is a potent competitive antagonist of the GIP receptor and effectively inhibits GIP-mediated insulin, glucagon, and somatostatin release

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And the larger clinical trial evidence (STEP 9 in knee osteoarthritis patients, the SLIM LIVER study) supports the view that the disproportionately larger loss of fat relative to LBM results in improved mobility and physical function, even when absolute LBM declines