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It should be noted that the musculoskeletal evidence base remains preclinical, a 2025 scoping review by McGuire and colleagues in Current Reviews in Musculoskeletal Medicine found no adequately powered randomised controlled trials

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Ipamorelin is a synthetic ghrelin-mimicking GHRP that selectively stimulates GH release without significant effects on cortisol or prolactin, and it is sold only as a research peptide with no FDA-approved medical use