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The discovery has revealed that natural plant polysaccharides possess the ability to exert antidepressant effects through the regulation of neurotransmitters and their receptors, modulation of the HPA axis, control of inflammatory responses, management of oxidative stress, modulation of neurotrophic factors, regulation of gut microbiota and tryptophan metabolism, as well as other pathways

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J Physiol Pharmacol 58:541-549 Goraca A, Skibska B (2008) Beneficial effect of -lipoic acid on lipopolysaccharide-induced oxidative stress in bronchoalveolar lavage fluid

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