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Design and synthesis of conformationally constrained glucagon-like peptide-1 derivatives with increased plasma stability and prolonged in vivo activity

How Semaglutide Works: Mimicking Natural GLP-1 Semaglutide works by mimicking the activity of the natural GLP-1 hormone, but with a longer half-life

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One of the most important is GLP-1 (glucagon-like peptide-1), which slows digestion, reduces appetite, and helps the pancreas release insulin

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