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Subcutaneous injection distributes the trauma across a larger rotation of sites
New delivery mechanisms, such as microneedle patches, sustained release implants, and targeted liposomal carriers, are being developed to enhance tissue targeting and minimize dosing frequency
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No efficacy endpoint anchors it in humans
At a concentration of 1000 g/mL and a power density of 500 mW/cm 2 , the temperature exceeded 50 C within 5 min, reaching the typical threshold for effective photothermal ablation [54]
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