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IGF-IR inhibitors resistance The high failure rate of anti-IGF-IR mAb/inhibitor monotherapy or combinational therapy in clinical trials promotes the investigators to inspect the mechanisms underlying resistance to IGF-IR inhibition in cancer and revisit the strategies to target IGF-IR pathway
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Cancer 47 , 12191230 (2011)
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Two recent in vitro studies by Alanteet et al
Meanwhile, ROS is also involved in maintaining protein homeostasis, affecting ribosome biogenesis, mRNA translation, endoplasmic reticulum oxidative folding, and protein degradation through the ubiquitin-proteasomes and autophagy pathways
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