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As a key angiogenic factor, EGFL7 promotes angiogenesis by activating the MAPK/ERK, PI3K/Akt, and JAK/STAT3 pathways, while also inhibiting Notch signaling and its target genes to further facilitate angiogenesis [118]

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Furthermore, an independent study of mannose supplementation suggested that mannose could improve insulin tolerance and reduce weight and body fat in mice with high-fat diets if supplemented at early stages [37]

This isn't arbitrary it's based on Khavinson's bioregulation framework and the protocols from the original St