Potential long-term effects could include joint pain and increased risk of diabetes due to altered glucose metabolism
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Additional research has explored its effects on gastrointestinal motility and metabolic signaling
Dialysis dependence or an estimated glomerular filtration rate below 30 mL min1 1.73 m2 represents an absolute contraindication unless the infusion is placed immediately before dialysis under nephrology supervision
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3 However, SUSTAIN 3 and other studies within the SUSTAIN series also reported significant weight loss as a benefit of semaglutide in addition to its blood sugar control properties