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Such variability likely reflects additional factors, including aging, obesity, hypertension, and dyslipidemia, that compound kidney injury and accelerate its progression

The appetite-suppressive effects create a secondary concern: patients taking both drugs may inadvertently restrict calories to unsafe levels, leading to nutrient deficiencies, muscle loss, or metabolic adaptation that undermines long-term weight loss

von Haehling S, Morley JE, Coats AJS, Anker SD