Evans, et al., Efficacy of a novel formulation of L-Carnitine, creatine, and leucine on lean body mass and functional muscle strength in healthy older adults: a randomized, double-blind placebo-controlled study, Nutr Metab (Lond), Jan 2017, 14:7
The IFEBP first conducted the survey in October 2023 and again in May 2024
Representative domains include: Gastrointestinal and hepatic models: Protection against ulcers, leaky gut, IBSlike symptoms, Crohntype inflammation, and toxic liver injury (e.g., CCl4, NSAID, and alcohol models), with improved mucosal healing and barrier integrity
Digestion-based DNA methylation analysis Percentage DNA methylation was assessed at CpG sites across CpG islands in CYP2R1, CYP27A1, CYP27B1, CYP24A1, and VDR genes using Qiagen EpiTect II methylation enzyme kits and PCR assays at the concentrations and cycle conditions recommended by the manufacturer
Overall, the evidence base is strong for GLP-1 receptor agonists in the management of obesity and T2D, with emerging evidence supporting the potential additional benefits of dual GLP-1/GIP receptor agonists
While women produce significantly less testosterone than men, the hormone is essential for maintaining muscle mass, bone density, mood regulation, and overall well-being