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Most gut peptide research has been conducted in rodent models, and while the mechanistic data is compelling, translation to human outcomes has not been established through large clinical trials

A previous study simulated the process and functions of mutant p53 proteins in vivo via mutant p53 reporters and traced the precancerous clones in nontumor tissue

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These examples do not include normal transfer or measurement loss

In a 16-week study of nightly GHRH-(1-29) dosing in older adults, nocturnal growth-hormone output stayed elevated across the full treatment period and IGF-1 rose and remained above baseline, with no sign of the pituitary becoming desensitized to nightly stimulation over those 16 weeks (Khorram et al., 1997)