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Most protocols run 4 to 12 weeks followed by a 2 to 4 week rest period
Beta cell incretin receptor activity drives insulin secretion, an essential component of the antidiabetic response to either GLP-1R or GIPR agonists 10,18
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A randomized trial is needed to show if the medication itself makes a meaningful difference
This is due, at least in part, to recent outcome trial data supporting the use of select GLP-1 RAs and SGLT-2 inhibitors to mitigate cardiovascular and renal risks in at-risk patients
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