Notably, propionate has been shown to directly stimulate GLP-1 release in controlled experimental settings, creating a positive feedback loop whereby GLP-1 RA-induced microbial changes lead to more SCFA production, which in turn further amplifies endogenous GLP-1 and PYY secretion (67)
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The polycyclic aromatic hydrocarbons that were studied, among other toxins, have been shown to be mutagenic, including mutations linked to cancer