doi:10.3389/fnins.2018.00073 175
The Link Between Obesity, Metabolic Disease and Inflammation Visceral fat actively secretes pro-inflammatory cytokines and adipokines, and significant weight loss as seen with retatrutide in Phase 2 trials is biologically plausible to reduce these markers, though direct anti-inflammatory effects remain unconfirmed
GLP-1RAs could fill a big gap, but they should be used wisely, preferably in conjunction with psychotherapy, not as a cure-all
This Review summarizes the role of NAD + metabolism in the heart and kidney, and highlights the mitochondrial sirtuins as mediators of some of the beneficial effects of NAD + -boosting therapies in preclinical animal models
PMID 25308577
They may reduce your dose, extend the time at the current level, or prescribe supportive medications like ondansetron for nausea management