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Adv Exp Med Biol (2010) 687:4963
Understanding the mechanisms by which peptides exert their therapeutic effects is crucial for optimizing their clinical applications
In the model proposed by Lee, homocysteine is shunted away from the methionine synthesis pathway and toward the GSH synthesis pathway, creating a relative deficiency of methyl donors in order to keep up with increased demand for the glutathione needed for POP conjugation ( Fig 3 )
462 ISGF3 translocates to the nucleus, where it binds to the IFN-stimulated response element (ISRE) to regulate the transcription of ISGs
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