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The absence of pharmacokinetic or pharmacodynamic interaction studies means healthcare providers must rely on theoretical considerations and the known pharmacology of each component when patients inquire about combination use
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34 These effects are achieved by the expression and translocation of apical glucose transporter type 4 (GLUT4) thus increasing glucose uptake and by the inhibition of pro-apoptotic proteins such as Bad, Bax and FOXO family proteins, thereby improving beta cell survival
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