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The STEP trials, which evaluated semaglutide for chronic weight management, revealed that lower doses activate GLP-1 receptor pathways sufficient to reduce hunger signals and improve appetite control

Fitch agrees that weight gain is likely to occur when someone stops taking a GLP-1 medication, so she recommends talking to your healthcare provider about more affordable options

Recent blood sugar levels and hemoglobin A1c results The date you started semaglutide and any dose changes All vision symptoms, even if they seem minor or temporary Other health conditions such as high blood pressure or kidney disease Any eye treatments, injections, or laser procedures you have had Existing diabetic retinopathy calls for enhanced vigilance when starting semaglutide

Before imputation, variants were filtered by call rate 5% missingness

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