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While transdermal patch delivery systems are under investigation, all commercially available GLP-1 therapies require subcutaneous injection (semaglutide, liraglutide, dulaglutide, tirzepatide) or oral administration (Rybelsus)

Each component has been selected for its distinct but complementary mechanism, and together they represent one of the most studied and replicated peptide combinations in growth hormone axis research

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Tirzepatide as a novel therapeutic option for patients with type 2 diabetes: a pooled analysis of subgroups of SURPASS 15 trials