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[1] Primary mechanisms: modulation of the nitric oxide (NO) system via upregulation of eNOS, activation of VEGFR2-Akt-eNOS signaling for angiogenesis, and enhancement of antioxidant defenses (HO-1 upregulation)

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This is particularly common in postpartum patients, perimenopausal women, and individuals under chronic stress

That case occurred in 2001 and involved the company GlaxoSmithKline (GSK), resulting in a settlement of $6.5 million

References Jastreboff AM, et al