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The presence of this extracellular lactate promotes the polarization of macrophages towards a resolution/repair phenotype, which contributes to tissue remodeling and immune tolerance [88] (Fig

The differences come down to scope and intensity of support

Although Th2-associated cytokines, such as IL-4 and IL-13, may promote fibrogenic responses, the overall contribution of Th2 cells to MASH is still inconclusive (127, 128) ( Figure 6A )

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