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Additionally, GLP-1 promotes the growth and proliferation of pancreatic cells, inhibits glucagon secretion, and enhances peripheral tissue uptake of glucose, making it a key factor in maintaining stable blood glucose levels
doi: 10.1016/j.jsps.2009.12.007 158
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Downstream activation of GLP-1R results in rapid activation of adenyl cyclase and increased cAMP secretion
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However it should be noted that the overall and off-label use of GLP-1R agonists in 2023 are likely underestimated in the published study, as it doesnt include the recently approved member of this group, tirzepatide (Mounjaro), which induces even greater weight loss than Ozempic
