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Canada is the standout country, notably a high GDP-per capita and a high exposure to OOP spend, as well as a substantial prevalence of adults living with obesity
Cardiovascular data on endpoints like MACE-3 or MACE-4 are presently not available yet, but an early meta-analysis demonstrated at least cardiovascular safety in patients with T2D treated with tirzepatide (78, 79)
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No evidence of genotoxic activity was found in either assay
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