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In 2013, a clinical trial of ketamine in treatment-resistant depression used midazolam as an active placebo, finding 64% responders for ketamine and 28% for midazolam (Murrough et al., 2013), while the antidepressant effect was also confirmed to occur in bipolar depression (Diazgranados et al., 2010)

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Explaining the long-term implications of their study, Dr

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