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Homocysteine is a thiol-containing amino acid, which suffers two major metabolic fates: remethylation catalyzed by methionine synthase (MS), methylenetetrahydrofolate reductase (MTHFR) or betaine-homocysteine methyltransferases (BHMT) and transsulfuration catalyzed by cystathionine -synthase (CBS) leading to cystathionine [3] (Figure 1)

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In addition, protein ingestion in close temporal proximity to resistance exercise appears to further potentiate hypertrophic adaptations, particularly in older adults

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