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Acromegaly occurs after these bones have fused (adults)
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44 Total RNA was reverse transcribed into first-strand complementary DNA and RT-PCR was performed using a LightCycler Real-Time PCR system (Roche, Switzerland) as previously described
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To further elucidate the therapeutic mechanisms underlying D-CuPs multivalent interactions, comprehensive proteomic analysis revealed two pivotal transcriptional regulators, the tumor suppressor protein p53 and histone deacetylase 7 (HDAC7) to be potential mechanistic targets
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