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Sous sa forme native, lIGF-1 est troitement rgul par ces protines, ce qui limite son activit libre circulante

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23 NADPH is also needed for dihydrofolate reductase (DHFR) enzyme to catalyze the reduction of dihydrofolate to tetrahydrofolate (THF) in folate metabolism, which is required for de novo biosynthesis of thymidylate, purines, methionine, and some amino acids

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10.1161/01.CIR.0000083716.82622.FD 5 BartkowiakJ.SpitzerE.KurmannR.ZurcherF.KrahenmannP.Garcia-RuizV.et al (2021)

Let's break down the concentration