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49,54 In addition, the large size of mRNA and its susceptibility to degradation by nucleases result in low cellular uptake, further limiting its application

This data indicates that other DJ-1 targets are involved in this phenotype

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(1) Echothiophate irreversibly inhibits acetylcholinesterase, resulting in accumulation of acetylcholine within the synaptic cleft

Yet GLP-1R knockdown in Sim1 neurons did result in a significant reduction in energy expenditure, in contrary to results from whole-body or hypothalamic GLP-1R knockout models