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Baseline characteristics of R and NR were not significantly different and no predictive factors, such as gender, anthropometric, clinical, and laboratory parameters, were found to explain the heterogeneity in the individual response to oral semaglutide in terms of weight loss (data not shown)

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Raw counts were normalized with the SCTransform function, and principal component analysis (PCA) was performed with the RunPCA function using the top 3000 variable genes as input

Semaglutide works by activating GLP-1 receptors, which stimulates insulin secretion in response to meals, reduces glucagon release, and slows gastric emptying

BPC-157 anchors local cytoprotective activity stabilizing cells under oxidative stress and modulating the NO system while TB-500 coordinates systemic recruitment of stem cells and progenitor cells