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Collectively, studies identify innate immune activation is driven by both central glial reactivity and peripheral microbial priming which act as a critical connection between gut dysbiosis, systemic inflammation, and neurodegeneration in PD [79]

Nutrients , 13 , 1060

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PMID 11278763

Markers of microbial dysbiosis, such as shifts in the Firmicutes/Bacteroidetes ratio, reduction in butyrate-producing species, and increased LPS levels, may serve as early indicators of circadian-gut axis dysfunction 260

PubMed DOI Kwack MH, Seo CH, Gangadaran P, et al