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Particularly noteworthy were the marked differences in serious metabolic and renal complications: lactic acidosis (monotherapy: n = 15,789 vs combination: n = 567), acute kidney injury (7694 vs 675), diarrhea (6922 vs 3890), and metabolic acidosis (4713 vs 203)
Cagrilintide combined with semaglutide (CagriSema) for treatment of type 2 diabetes In a recent small phase 2 trial (n=92), 3 groups of patients with type 2 diabetes were randomized to receive cagrilintide co-administered with semaglutide (the authors called this combination CagriSema), cagrilintide or semaglutide, both in doses escalated to 2.4 mg once weekly (table 1) [10]
It has been shown that Nrf2 modulates the GSH redox state via glutathione reductase regulation
The clinical message is not that GLP-1 receptor agonists should now be viewed as anticancer therapy
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