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Foods that once tasted normal can suddenly seem off-putting or intolerable

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Indeed, VPA promotes the transport of glutamine through the mitochondrial membrane, thereby enhancing glutaminase activity

In hypertensive states, mitochondria generate excessive ROS due to electron transport chain (ETC) disruption, particularly at complexes I and III, coupled with reduced antioxidant defenses (e.g., Mn-SOD) (Grossini et al., 2025)

This should be taken into account in the small number of affected individuals with PWS and growth failure who exhibit normal growth hormone responses after standard stimulation tests (109)