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Bioavailability via non-injection routes is essentially zero for both
This led to the name gastric inhibitory polypeptide. Later studies showed that GIP had a much stronger insulinotropic effect especially in the presence of glucose
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When GLP-1 interacts with GLP-1R, this triggers cyclic adenosine monophosphate (cAMP) formation and initiates subsequent pathways (2)
Cell 172 , 393407 (2018)
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