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Although an important case study, it is critical to note that the human gamma globulin was isolated from the plasma of thousands of healthy volunteers resulting in a heterogeneous product

This tissue distribution is pharmacologically relevant because GLP-1 receptors are expressed not only in the pancreatic islets (where they mediate insulinotropic effects) but also in the gastrointestinal tract (where they slow gastric emptying), the hypothalamus and brainstem (where they mediate appetite suppression), the cardiovascular system (where they may confer cardioprotective effects), and the kidneys (where they promote natriuresis)

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The Trp cage was believed to interact with nGLP-1R and thereby explain the superior affinity of Exendin-4

Vogel C, Silva GM, Marcotte EM (2011) Protein expression regulation under oxidative stress

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