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Expect irregular cycles during rapid weight loss phase, typically heavier or lighter flow, cycle length changes of 3-7 days, or temporary absence of periods if losing weight very quickly
Characteristics of therapeutic GLP-1R agonists Endogenous GLP-1 is characterized by a very short half-life of only few minutes, as it is quickly degraded by dipeptidyl peptidase-4 (DPP4), an enzyme expressed in many different types of tissues
In the phase 2 trial, 41% to 63% of participants receiving cagrilintide (0.3 to 4.5 mg) experienced gastrointestinal adverse events, compared to 32% with placebo
The patient now has a worse metabolic condition but better insurance coverage
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