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GHK-Cu is commonly studied for copper-peptide signaling and extracellular matrix communication, while KPV is examined for localized regulatory signaling behavior in epithelial and barrier-associated systems

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Next Steps in Research As research in this area continues, the authors emphasize the need for: Larger, diverse cohort studies with lifelong dietary tracking Better differentiation of artificial sweetener types and formulations Mechanistic research exploring vascular, metabolic and neurobiological pathways Investigation into the interactions between beverage choices and social or behavioral factors As the landscape of artificial sweeteners continues to evolve, understanding their longterm effects on brain health will be essential

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