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In-Depth Review of Potential Blockbusters Keytruda Qlex (pembrolizumab + berahyaluronidase alfa-pmph) Projected peak annual sales: USD 9.3 billion Keytruda Qlex is a subcutaneous injection formulation of pembrolizumab, a programmed death receptor-1 (PD-1)-blocking antibody, and berahyaluronidase alfa, an endoglycosidase which enhances dispersion and permeability to enable subcutaneous administration of pembrolizumab

It occurs naturally in human plasma, saliva, and urine, and its plasma concentration declines significantly with age, from approximately 200 ng/mL in young adults to much lower levels in older individuals

NAT1 appears to be ubiquitous