The lack of clear guidance on optimal positioning and sequencing of SGLT2is and GLP-1 RAs is, in part, due to limited direct comparative data on the two agents
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Here is a simple way to think about it: Daily intake: 500800 calories What it may mean: Often too low if happening regularly Daily intake: 9001100 calories What it may mean: May still be too low for many adults, especially without protein Daily intake: 12001600 calories What it may mean: Common realistic range for many GLP-1 weight-loss users Daily intake: 1600+ calories What it may mean: May still support weight loss depending on body size and activity Daily intake: Any number with very low protein What it may mean: Higher risk of muscle loss and weakness For a fuller eating structure, see my GLP-1 diet plan guide
Richard Siegel, co-director of the Diabetes and Lipid Center at Tufts Medical Center and Endocrinologist at Tufts Medicine Weight and Wellness CenterStoneham
Examples include anxiety and agitation
Throughout the follow-up period, HbA1C levels remained consistently higher in the GLP-1 RAs group (Figure S1)