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(1996) Effects of vitamin B12 on performance and circadian rhythm in normal subjects

its use is constrained by lesion accessibility, intratumoral distribution, repeat dosing feasibility and the risk of treating only selected lesions in multifocal disease

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The goal is to place the needle tip in the middle of the fatty layer, not at the skin surface (too shallow, causing intradermal injection) and not at the muscle fascia (too deep, causing IM injection)

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