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The Wegovy pill is another oral GLP-1 with semaglutide, but its approved for weight loss and cardiovascular risk reduction in adults with obesity or overweight

Aging cell, 25(2), e70364

10.1038/nm919 35

However, small-molecule 3 was quite lipophilic (logD 7.4 = 5.7), resulting in high metabolic intrinsic clearance in human liver microsomes (HLM) (CL int = 130 mL/min/kg, Table S4), which would likely lead to a short pharmacokinetic half-life (t 1/2 ) and the requirement for an unacceptably high daily dose in humans

Diabetes 58 , 299301 (2009)

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