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Return to baseline depends on how long you used semaglutide and whether you've maintained behavioral changes from treatment
Most adverse effects associated with tirzepatide are mild to moderate in severity and tend to improve with continued use as the body adapts to the medication
Research in animal models has shown that GLP-1 receptor activation dampens dopamine release in response to rewarding stimuli
Moreover, Balogh et al
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The 2023 American Association of Clinical Endocrinology (AACE) Comprehensive Type 2 Diabetes Algorithm recommends adding an SGLT2 inhibitor with outcomes data when a patient with atherosclerotic cardiovascular disease, CKD, or heart failure does not achieve glycemic targets on metformin alone, placing canagliflozin among the preferred second-line agents in those patient groups [21]
