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What they found (summary): MC1R: melanogenesis, pigmentation, anti-inflammation MC2R: ACTH receptor in the adrenals (Melanotan II does not act) MC3R: energy, cardiovascular function, anti-inflammation MC4R: appetite (central control), sexual function, autonomic regulation MC5R: exocrine glands (sebaceous, lacrimal, salivary) Mutations in MC4R are the most common monogenic cause of obesity in humans Why it matters: Cones review article is the reference article for all of melanocortin pharmacology
Diabetes 54: 2734-2743, 2005
Hwang SY, Oh H, Rhee MY, Kang S, Kim HY
Improves Sleep Quality : May reduce oxidative damage linked to sleep apnea, promoting deeper, more restorative rest
For this reason, it is not recommended for pregnant or lactating mares unless specifically advised by your veterinarian
