No arm in SURMOUNT-1 stayed at 2.5 mg
PMC8615275 Research use only
Timing matters: Take melatonin three hours before bed for best results
In addition, conditions such as pregnancy, eating disorders, pancreatitis history, cardiovascular disease, and substance use disorders may affect which medications are safe to use
Required materials: Lyophilized tirzepatide vial (5mg, 10mg, 15mg, or 30mg) Bacteriostatic water (0.9% benzyl alcohol preserved) 3 mL or 5 mL syringe with an 18 to 21 gauge drawing needle Insulin syringes for dosing (U-100, 29 to 31 gauge, 0.3 mL or 0.5 mL) Alcohol swabs (70% isopropyl) Fine-point marker or label tape Clean, flat work surface Optional but recommended: Sharps container for used needles Nitrile gloves 0.22 micron syringe filter (if concerned about particulate contamination) The drawing syringe is for transferring water into the peptide vial
A list of the key used materials is available in Table S1