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The medication targets the glucagon-like peptide-1 receptor (GLP-1R) to help reduce appetite, slow gastric emptying, and improve insulin secretion
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Therefore, the glycaemic improvement in animals treated with a GLP-1R/GcgR co-agonist is attributable to body-weight-independent and -dependent effects
Another important consideration with all incretin drugs is that the effects only last as long as the drug is being used
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Accelerating titration increases side effect risk (nausea, vomiting, GI discomfort) and doesn't necessarily accelerate fat loss proportionally
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