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The SGLT2i treated cohort experienced higher rates of diabetic ketoacidosis (DKA) (RR 2.08 [95% CI 1.05, 4.12] p =0.0309) and urinary tract infection/pyelonephritis (RR 2.27 [95% CI 1.12, 4.55] p =0.019) compared with the GLP-1 RA treated cohort

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Mice were exposed to CS for 3 days to achieve an adaptive GSH level of roughly 250 M and they were sacrificed immediately after the third day of CS exposure or after 16 hours of rest (Figure 6)

Eli Lilly is currently in Phase 3 clinical trials with orforglipron