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Most adverse effects diminish after 812 weeks, and long-term monitoring shows sustained weight loss and metabolic benefits when medication is continued with regular healthcare oversight
In patients with MCAS, ongoing mediator release (histamine, prostaglandins, leukotrienes, cytokines) can drive: Visceral hypersensitivity Chronic neuropathic-type pain Heightened itch signaling Sleep disruption Central amplification of sensory input Even when mast cell activity is partially controlled, neural sensitization may persist
Receptor Sensitivity: The Why Behind Cycling Just like insulin receptors can become resistant with constant sugar exposure, peptide receptors can downregulate or desensitize if overstimulated
p = 0.0001)
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Science 337 , 975980 (2012)
