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PDE-5 modulators primarily influence vascular function

Regarding metabolic parameters, GLP-1 RAs significantly improved triglycerides, markers of insulin resistance and fasting and postprandial plasma glucose

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Geneva: World Health Organization (2006)

Coskun T, Sloop KW, Loghin C, Alsina-Fernandez J, Urva S, Bokvist KB, Cui X, Briere DA, Cabrera O, Roell WC, Kuchibhotla U, Moyers JS, Benson CT, Gimeno RE, DAlessio DA, Haupt A

After 30 days on the 1.5 mg dose, increase the dose to 4 mg once daily