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5-amino-1-methylquinolinium) combined with low-fat diet (LD) promoted dramatic whole-body adiposity and weight loss in diet-induced obese (DIO) mice, rapidly normalizing these measures to age-matched lean animals, while LD switch alone was unable to restore these measures to age-matched controls in the same time frame

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However, due to their reversibility, these side effects do not pose any lasting danger

What the studies tell us so far The current evidence is promising but uneven

We prioritized genes belonging to several biological classes related to kidney function based on: missense variants (either the lead or a proxy variant, 34 genes), DEPICT gene prioritization results (156 genes), significantly colocalized eQTLs in either kidney (4 genes) or non-kidney (187 genes) tissue, or nearby Mendelian kidney-disease genes (Supplementary Tables 12, Supplementary Data 24)

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