In the Phase 2 trial published in the New England Journal of Medicine in 2023, the most common side effects were gastrointestinal and dose-related, mostly mild to moderate
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"While semaglutide can be a valuable tool, it's crucial to have realistic expectations," says Dr
Retatrutide TRIUMPH-1: Lilly's New Phase 3 Obesity Data Just Raised the Bar Again On May 21, 2026, Eli Lilly announced TRIUMPH-1 Phase 3 results for retatrutide
Hazard ratios (HRs) at 1, 3, and 5-year follow-up periods were calculated using Cox proportional hazards analysis
These medications work by mimicking GLP-1s multiple mechanisms: they slow gastric emptying (keeping you full longer), suppress glucagon release from the pancreas (reducing glucose production), stimulate insulin secretion when blood sugar is elevated, and most importantly for weight loss, directly activate satiety centers in the brains hypothalamus